Cancer Prevention Study-3 (CPS-3)

The Cancer Prevention Study-3 (CPS-3) is a large, geographically and racially/ethnically diverse US cohort of 300,000 participants who were cancer free when they enrolled between 2006 to 2013 and who are continuing to be studied.

CPS-3 News & Announcements

2024 Triennial Survey Has Launched
Online survey ready for you to answer.

Previous News: CPS-3 Participants Newsletter Archive

English and Español 

CPS-3 Participant Portal

We're launching the Participant Portal with a whole new design and platform.

Substudies & Tools

In addition to the triennial follow-up surveys we send, we also invite CPS-3 participants to volunteer for substudies, which allow smaller cohorts to collect more detailed information for more targeted research about specific risk factors for cancer, such as physical activity.

CPS-3 Repeat Blood Collection Substudy

ACS CPS-3 participants are asked to donate a second blood sample to evaluate biological and genetic risk factors for cancer.

CPS-3 Accelerometry Sub-Study Tracks Participants’ Daily Activity

This study invited 20,000 CPS-3 participants to wear an activity monitor for 7 days to understand the effects of physical activity and sitting time on health.

CPS-3 Participants Send Stool Samples for the Sake of Science

The study aims to collect over 10,000 stool samples from CPS-3 participants to study how the gut microbiome affects health and the risk of cancer.

COVID-19 Symptom Tracker

The American Cancer Society invited CPS-3 participants to use a new app, the COVID Symptom Tracker, to help ACS investigators track the COVID-19 epidemic and inform future research efforts.

Why Our Participants Remain Dedicated to CPS-3

There's no better way to understand the impact of CPS-3 on cancer research than to hear some participants and researchers talk about their motivation for becoming involved and why they're committed for the long haul"

Alpa V. Patel, PhD

Senior Vice President, Population Science

American Cancer Society

How CPS-3 Participants Are Contributing to Cancer Research

Many studies published by American Cancer Society researchers and other researchers across the United States use data from the Cancer Prevention Studies (CPS-II and CPS-3) and substudies. 

Here are some recent articles on cancer.org that describe such studies. We couldn't have made these findings without participants who took the time and made the effort to answer surveys, wear accelerometers, and supply samples of blood, urine, and saliva.

CPS-3 Accelerometry Substudy

Replacing 30 Min. of Sitting with Activity or Sleep May Affect Weight

CPS-3 Accelerometry data showed how replacing 30 minutes of the day's sedentary time with other behaviors can affect weight.

CPS-3 Blood Sample Substudy

Black Women Need Genetic Testing for Breast Cancer Too

A study including CPS-II/3 survey and blood data finds that both Black and White women need genetic counseling/tests to predict the risk of breast cancer.

CPS-3 Diet Assessment Substudy

Researchers Ask What People Eat—and Check Urine Samples

A study led by Ying Wang, PhD, in the journal Metabolites identified 513 unique metabolites correlated with 79 food groups/items. Learn more.

CPS-3 Infographics

What Is CPS-3? Infographic

Who Is in CPS-3? Infographic

Why Is CPS-3 Important? Infographic

CPS-3 Timeline Infographic

Contact Us

CPS-3 participants: 
CPS3@cancer.org
888-604-5888 Mon.-Fri. 9 AM – 5 PM EST 
CPS-3 FAQs

Researchers:
Learn about Data Access Policies and Procedures

Other inquiries:
Contact: Alpa V. Patel, PHD, Senior Vice President, Population Science
alpa.patel@cancer.org